目的 观察2型糖尿病(T2DM)合并高血压病人血清中25羟维生素D[25(OH)D]、尿酸(UA)水平,并分析25(OH)D与UA的关系.方法 随机数字表法选取T2DM病人77例,按有无高血压分为正常血压组(DM组)38例(男19例,女19例)及高血压组(DH组)39例(男18例,女21例),另选同期体检中心健康体检者(NC组)32例(男17例,女15例).其中女性病人均未绝经,同时NC组中的女性均选择年龄及体质量指数(BMI)匹配的未绝经健康女性.三组病人年龄、性别构成比比较,均差异无统计学意义.检测血清25(OH)D和UA水平及各项临床生化指标.结果 DM组血清25(OH)D水平[(12.48±4.01)μg·L-1]低于NC组[(26.73±9.59)μg·L-1],而UA水平[(316.61±85.91)μmol·L-1]较NC组[(273.03±60.92)μmol·L-1]升高,均差异有统计学意义(P<0.05);DH组血清25(OH)D水平[(7.36±3.63)μg·L-1]明显低于NC组[(26.73±9.59)μg·L-1],而UA水平[(362.07±117.76)μmol·L-1]较NC组[(273.03±60.92)μmol·L-1]明显升高,均差异有统计学意义(P<0.05);DH组血清25(OH)D水平[(7.36±3.63)μg·L-1]低于DM组[(12.48±4.01)μg·L-1],而UA水平[(362.07±117.76)μmol·L-1]较DM组[(316.61±85.91)μmol·L-1]明显升高,均差异有统计学意义(P<0.05).Pearson相关性分析显示25(OH)D与UA成负相关(r=-0.259,P=0.010).结论 血清25(OH)D水平减低及UA水平升高是T2 DM合并高血压的重要危险因素.%Objective To detect the levels of the serum 25-hydroxyvitamin D [25 (OH)D],uric acid in the type 2 diabetes mellitus (T2DM)with hypertension patients and analyze the relationship between 25(OH)D and uric acid(UA).Methods Outpatientsand inpatients with T2DM hospitalized in 77 cases without hypertension were divided into normal blood pressure group (DMgroup)38 ca-ses (male 19 cases,female 19 cases)and hypertension group (DH group)39 cases (male 18 cases,female 21 cases),healthy physical examination over the same period physical examination center (NC group)32 cases (male 17 cases,female 15 cases).Female patients were premenopausal women,while women in the control group were selected for age and BMI matched healthy premenopausal women. There was no significant difference in age and sex composition between the three groups.The measurement of serum 25 (OH)D and UA and other clinical biochemical indices were performed for all patients and subjects for observation. Results In the DM group,serum25 (OH)D level [(12.48 ±4.01)μg·L-1 ]was less than NC group[(26.73 ±9.59)μg·L-1 ],while the UA level [(316.61 ± 85.91)μmol·L-1]higher than that ofNC group[(273.03 ±60.92)μmol·L-1],and the difference was statistically significant (P<0.05).DH serum 25 (OH)D levels [(7.36 ±3.63)μg·L-1 ]were significantly lower than NC group[(26.73 ±9.59)μg·L-1 ], and UA levels [(362.07 ±117.76)μmol·L-1]were significantly higher than the NC group [(273.03 ±60.92)μmol·L-1],the difference was statistically significant (P<0.05).Serum 25 (OH)D levels [(7.36 ±3.63)μg·L-1 ]in DH group was lower than that in DMgroup[(12.48 ±4.01)μg·L-1],while the UA level [(362.07 ±117.76)μmol·L-1]was significantly higher than the DMgroup[(316.61 ±85.91)μmol·L-1],the difference was statistically significant (P<0.05).Pearson Correlation analysis showed that25(OH) D to a negative correlation with UA (r=-0.259,P=0.010).Conclusion The decrease of serum 25(OH)Dlevel and the increase of UA level are important risk factors for type 2 diabetes complicated with hypertension.
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