基于代谢组学的支气管哮喘生物标志物研究进展

摘要

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation,with recurrent wheezing,coughing,chest tightness,shortness of breath and reversible airflow limitation as the main clinical features.Bronchial asthma is the most common chronic respiratory disease of children.In recent years,its prevalence rate in the world tended to rise.Without timely and effective treatment,it will defer to adult and affect the child's physical and mental health.Metabonomics is about researching the whole and the changing of the endogenous metabolism of biological system that is stimulated or disturbed.This review is to summarize the advances of the application of the metabonomics in the study of the biomarkers of bronchial asthma.%支气管哮喘是以反复发作的喘息、咳嗽、胸闷、气促、可逆性气流受限为主要临床表现,是一种慢性气道炎症的异质性疾病.支气管哮喘是儿童最常见的慢性呼吸系统疾病,其患病率在世界范围内呈上升趋势,若得不到及时有效的治疗,常迁延至成年,严重影响患儿的身心健康.代谢组学是关于生物体系受刺激或扰动后其内源性代谢物质的变化及其变化规律的科学.该文就近年来代谢组学应用于支气管哮喘生物标志物研究的进展作一简单综述.