端粒长度与动脉粥样硬化性脑梗死及斑块稳定性的相关研究

摘要

目的 探讨端粒长度与动脉粥样硬化性脑梗死及颈动脉斑块稳定性之间是否相关.方法 选取急性前循环动脉粥样硬化型脑梗死患者70例作为观察组并根据超声结果 将其分为稳定斑块组及不稳定斑块组,同时选取健康体检者68例作为对照组.通过实时荧光定量PCR法测定外周血白细胞端粒长度.比较观察组与对照组以及稳定斑块组与不稳定斑块组的端粒长度是否存在差异.结果 观察组与对照组的外周血白细胞端粒长度差异有统计学意义(P<0.05).不稳定斑块组与稳定斑块组外周血端粒长度差异有统计学意义(P<0.05).结论 端粒长度与动脉粥样硬化性脑梗及动脉粥样硬化斑块稳定性之间有相关性.%Objective To investigate the relationship between telomere length and atherosclerotic cerebral infarction and plaque stabili-ty.Methods Seventy patients with acute cerebral infarction were randomly divided into stable plaque group and unstable plaque group.Sixty-eight healthy subjects were selected as the control group.The telomere length of peripheral blood leukocytes was determined by real-time fluorescence quantitative PCR.There was a difference in the telomere length between the case group and the control group and the stable plaque group and the unstable plaque group.Results The telomere length of peripheral blood leukocytes in the case group and the control group was statistically significant (P <0.05).There was a significant difference in telomere length between the unstable plaque group and the stable plaque group (P <0.05).Conclusion There is a correlation between telomere length and the stability of atherosclerotic cerebral infarction and atherosclerotic plaque.