磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白信号通路参与中枢神经损伤保护与修复的研究进展

摘要

The central nerve cells are difficult to tolerate of various kinds of damage,and difficult repair after injury.Therefore,it is cru-cial to promote neural regeneration to nerve protection.The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.It plays a central role in cell proliferation,growth and differentiation.The activation of the PI3K/AKT/mTOR signaling pathway can reduce the death of nerve cells and promote nerve repairduring nerve damage.This paper reviewed PI3K/AKT/mTOR signaling pathway in central nervous damage protection,repair mechanisms and possible risksas to exploreuse.The PI3K/AKT/mTOR signaling pathway as a target treatment of central nervous disease.%中枢神经细胞对各种损伤刺激耐受差,损伤后神经修复困难.因此促进神经保护增强神经再生能力已成为神经治疗关键.磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白(PI3K/AKT/mTOR)信号通路是调节细胞周期的重要通路,在细胞增殖、生长、分化过程中起中心调控作用,在神经损伤过程中通过激活PI3K/AKT/mTOR信号通路可减少神经细胞死亡,促进神经修复.该文对PI3K/AKT/mTOR信号通路在中枢神经损伤保护作用、修复机制及可能风险作一综述,探讨将PI3K/AKT/mTOR信号通路作为靶点治疗中枢神经疾病.