一直以来,强化调脂或“越低越好”的调脂观点在人们头脑中占据着重要地位,但2008年公布的ENHANCE研究结果给人们以警醒,同时也使调脂观念进入十字路口.实际上从血脂与动脉粥样硬化的关系看,不仅是“低密度脂蛋白胆固醇和总胆固醇”在动脉粥样硬化发病中起重要作用,“三酰甘油、高密度脂蛋白胆固醇、载酯蛋白”等在其中均有着重要作用,而具体患者还有着其遗传、疾病史、家庭收入等特殊性,所以我们认为调脂治疗不仅强调“胆固醇”达标,更要强调“综合调脂与个性化治疗相结合”的观点.%For many years the mantra "the lower the better" was the cornerstone of lipid-tnodulation in coronary artery disease (CAD). However, this was challenged after the results of the ENHANCE study were presented. It was shown that many lipid related factors are important in the pathological process of CAD including low-density lipoprotein-cholesterol ( LDL-C) , total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), and apolipoprotein. In addition, genetics and diseases affect the relationship between lipids and CAD. Therefore this article emphasizes the use of therapeutic strategies for CAD that focus not on just cholesterol levels, but also on factors presented by the ENHANCE study.
展开▼
