舒肝解郁胶囊联合舍曲林治疗老年抑郁症的临床疗效观察

摘要

Objective:To investigate the curative effect on senile depression treated by Shugan Jieyu capsule combined with sertraline .Methods:Select 160 cases of senile depression patients and they were divided into observation group and control group with 80 cases in each group .According to double-blind principle ,observation group was given the Shugan Jieyu capsule combined with sertraline therapy , and the control group was treated with sertraline .Observe and compare the HAMD score changes , clinical efficacy and adverse reactions in two groups .Results:8 weeks after treatment , HAMD scores of two groups were markedly improved , and the improvement of observation group was obviously better than that in the control group;total effective rate ( 92 .5%) of the observation group was obviously higher than that of control group (68.75%);the incidence of adverse reactions of observation group (21.25%) compared with that of con-trol group (18.75%), and there was no significant difference (P>0.05).Conclusion:The clinical curative effect on senile depression treated by Shugan Jieyu capsule combined with sertraline is distinct , high safety and worth clinical pro-motion.%目的：探讨舒肝解郁胶囊联合舍曲林治疗抑郁症老年患者的临床疗效。方法：选取160例老年抑郁症患者，按双盲原则随机分为观察组和对照组各80例，观察组采用舒肝解郁胶囊联合舍曲林治疗，对照组采用舍曲林治疗，观察并比较两组患者的HAMD的评分变化、临床疗效及不良反应发生率。结果：治疗8周后，两组的HAMD评分均较治疗前明显改善，观察组的改善情况明显优于对照组观察组的总有效率（92．5％）明显高于对照组（68．75％），观察组不良反应发生率（21．25％）与对照组（18．75％）比较无显著性差异（ P＞0．05）。结论：舒肝解郁胶囊联合舍曲林治疗老年抑郁症患者，临床疗效显著，安全性高，值得临床推广。