补肾强督祛湿法治疗肾虚督寒型强直性脊柱炎的临床疗效评价

摘要

目的:观察补肾强督祛湿法治疗肾虚督寒型强直性脊柱炎的疗效.方法:将强直性脊柱炎患者80例采用随机分组法分为两组,治疗组(40例)采用补肾强督祛湿法(鹿角胶,附子,金毛狗脊,桑寄生,葛根,白芍,茯苓,生甘草,青风藤,威灵仙等组成)治疗,每日1剂,分2次早晚口服;对照组(40例)采用柳氮磺胺吡啶治疗,两组治疗周期均为3个月.观察两组治疗前后中西医临床症状、体征,治疗前后免疫指标;安全性指标血尿常规、肝功能、肾功能的检测.结果:治疗组运用补肾强督祛湿法后中西医临床症状、体征及实验室检测,均有不同程度改善,与治疗前比较,差异有统计学意义(P<0.05);长期服用安全性指标血、尿、便常规,肝、肾功能未见明显改变.结论:补肾强督祛湿法治疗肾虚督寒型AS效果满意,疗效较确切,为治疗强直性脊柱炎提供一条新的途径.%Objective: To observe tHe effect of kidney-reinforcing, Governor VesseL (GV)-strengtHening and dampness-removing tHerapy for ankyLosing spondyLitis(AS) of kidney-deficiency and coLdness in Governor VesseL pattern.MetHods: 80 cases of AS were randomLy divided into two groups.THe treatment group (40 cases) was treated witH reinforcing tHe Kidney, strengtHening GV and removing dampness metHod (Lujiao Jiao, Fuzi, Jinmaogouji, SangjisHeng, Gegen, BaisHao, FuLing, SHenggancao, Qingfengteng and WeiLingxian incLuded in tHe decoction, oraLLy taken twice a day);tHe controL group (40 cases) was treated witH SuLfasaLazine.BotH groups were treated for tHree montHs.CLinicaL symptoms, signs and immune indexes were observed before and after treatment in botH groups;safety indicators of routine bLood and urine test, Liver and renaL function were tested.ResuLts: THe cLinicaL symptoms, signs and Laboratory tests of tHe treatment group were improved significantLy after treatment compared to tHose before treatment(P<0.05).Indicators of bLood and urine routine test, functions of Liver and kidney sHowed no obvious cHange.ConcLusion: Kidney-reinforcing, GV-strengtHening and dampness-removing tHerapy is an effective treatment for AS.It provides a new way for tHe treatment of tHis kind of disease.