复合麻醉剂KMT对八眉猪血流动力学及肾素-血管紧张素-醛固酮系统的影响

摘要

In order to investigate the effects and mechanisms of KMT on hemodynamics in Bamei pigs,eight healthy Bamei pigs of eight-week-old were received intramuscular injected KMT 0.1 mL/kg,and blood was collected in 0 min,5 min,10 min,15 min,30 min,45 min,60 min,80 min,100 min and 120 min,at the same time,noninvasive blood pressure(NIBP)and heart rhythm(HR) were monitored.Plasma renin(PRA),angiotensin Ⅱ (AⅡ) and aldosterone(ALD) were determined by radioimmunoassay.The results showed that NIBP and HR were increased after injection and reached the highest at 10 min and then decreased until 80 min,after that time NIBP and HR were increased.PRA,AⅡ and ALD were changed similar to that of SBP,DBP,MAP and HR,and correlation between them was found,particularly in SBP,DBP and MAP.The conclusion showed that PRA,AⅡ and ALD participated in change of hemodynamics caused by KMT,and R-A-A-S caused by KMT in Bamei pigs maybe one of the main reasons for changing blood pressure.%为探讨复合麻醉剂KMT对八眉猪血流动力学的影响及其作用机制,给8只8～10周龄的八眉猪根据体质量肌肉注射KMT 0.1 mL/kg,在注药前及注药后5、10、15、30、45、60、80、100、120 min进行无创血压、HR的监测,并同步采取前腔静脉血样,采用放免法测定血浆中PRA、AⅡ和ALD的质量浓度.结果发现,血压和HR在注药后10 min时达到最高值,之后开始逐渐下降,到80 min时降至最低,之后开始升高.PRA、AⅡ和ALD与SBP、DBP、MAP及HR的变化趋势大致相似,且存在一定的相关性.表明PRA、AⅡ和ALD参与KMT引起的八眉猪血流动力学变化过程,肾素-血管紧张素-醛固酮系统的变化可能是KMT引起八眉猪血流动力学变化的主要作用机制之一.