遗传性抗凝血酶缺乏合并高同型半胱氨酸血症与静脉血栓栓塞性疾病

摘要

高凝状态是遗传因素和后天危险因素相互作用的结果,其过程涉及凝血抗凝系统中多个反应.遗传性抗凝血酶缺乏是所有遗传性易栓症中静脉血栓栓塞性疾病(VTE)风险最高的,高同型半胱氨酸血症也被证明与VTE相关.本文总结了遗传性抗凝血酶缺乏和高同型半胱氨酸血症在VTE中的作用及该领域的研究进展.%Hypercoagulability state is the result of the interplay of genetic predisposition and risk factors. Many key enzymes and reactions in coagulation and anti-coagulation system are involved. Hereditary antithrombin deficiency is one of the major risk factors of venous thromboembolic disease (VTE) , whereas hyperhomocysteinemia may also play a role. This article reviews the recent researches on the contributions of these two factors to VTE.