三维准连续式动脉自旋标记灌注成像在定量高血压患者脑血流动力学变化中的应用

摘要

目的 采用三维准连续式动脉自旋标记(3D pCASL)技术定量分析轻中度高血压患者脑血流动力学变化.方法 58例高血压患者和34例年龄相匹配的健康志愿者在3.0T MR扫描仪上行全脑3D pCASL扫描.基于3D pCASL序列获得脑血流(CBF)图,采用统计参数图8提取各脑区的CBF值,采用手绘法获取各脑白质区的CBF值.结果 与健康对照组相比,高血压患者CBF在双侧半卵圆中心(P =0.000,P=0.000)、侧脑室旁白质(P =0.001,P=0.002)、胼胝体压部(P =0.003)、额叶(P =0.003)、顶叶(P=0.014)、枕叶(P =0.002)、颞叶(P =0.006)、延髓(P=0.012)、脑桥(P=0.016)、中脑(P =0.034)、小脑(P =0.000)及灰质(P =0.001)均明显降低,而在丘脑、苍白球、壳核及胼胝体膝部的CBF值差异均无统计学意义(P均＞0.05).结论 3D pCASL序列在高血压患者常规磁共振成像序列阴性时即可探测到血流动力学的变化,这些CBF下降的区域提示可能增加了高血压相关脑小血管病发生的风险.%Objective To investigate the cerebral hemodynamic changes in hypertensive patients using 3D pseudo-continuous arterial spin labeling (3D pCASL).Methods Fifty-eight hypertensive subjects and thirty-four age-matched healthy volunteers were recruited and scanned using the 3D whole-brain pCASL sequence.The regional cerebral blood flow (CBF) values were achieved based on 3D pCASL with SPM8 technique and were manually drawn.Results Compared with healthy volunteers,hypertensive patients had significantly lower CBF values in various regions,with statistical difference at the bilateral centrum semiovale (P =0.000,P =0.000),periventricular white matter (P =0.001,P =0.002),splenium of corpus callosum (P =0.003),frontal lobe (P =0.003),parietal lobe (P =0.014),occipital lobe (P =0.002),temporal lobe (P =0.006),medulla (P =0.012),pons (P =0.016),midbrain (P =0.034),cerebellum (P =0.000),and gray matter (P =0.001).Nevertheless,the CBF values in the thalami,globus pallidus,putamen,and genu of corpus callosum demonstrated no significant inter-group difference (all P ＞ 0.05).Conclusions 3D pCASL can be used to detect the subtle hemodynamic abnormalities even at the early stage of hypertension.The observed decrease in CBF in these regions may suggest an increased risk of cerebral small vessel diseases.