Objective To evaluate the expression of hypoxia-related carbonic anhydrase-9(CA-9) in colorectal carcinoma and its possible relation with clinical and pathologic indications of colorectal carcinoma. Methods Expression of CA-9 in 43 cases of colorectal carcinoma was detected with immunohistochemical method and its relation with pathological grade, clinical stage, and metastasis of colorectal carcinoma was evaluated. Results The positive and negative CA-9 expression was in 25 and 18 cases of colorectal carcinoma, respectively. The CA-9 expression was closely related with the invasion depth (P=0.005), lymph node metastasis(P=0.040), histological grade(P=0.047), and clinical stage(P=0.002) of colorectal carcinoma. Conclusion The positive expression rate of CA-9 is high in metastatic colorectal carcinoma, indicating that CA-9 may be an effective prognostic factor for colorectal carcinoma.%目的 评价缺氧相关蛋白碳酸酐酶-9(CA-9)在结直肠癌中的表达及与临床病理指标的可能关系.方法 采用免疫组织化学方法检测43例结直肠癌CA-9的表达,并评价它们与病理分级、临床分期、转移之间的关系.结果 43例结直肠癌组织CA-9表达阳性25例,阴性18例.CA-9的表达与结直肠癌肠壁浸润深度(P=0.005)、淋巴结转移(P=0.040)、肿瘤病理分级(P=0.047)及临床分期(P=0.002)以及远处转移情况(P=0.035)密切相关.结论 CA-9在转移组中的阳性表达率高,提示可能是有效的预后因子.
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