中国人群GSTM1基因多态性与非吸烟肺癌发病风险的Meta分析

摘要

Objective To assess the correlation between glutathione S-transferase Ml (GSTM1) polymorphism and risk of developing lung cancer in non-smoking Chinese by meta-analysis. Methods Papers on the correlation between GSTM1 polymorphism and risk of lung cancer in non-smoking Chinese were searched from CNKI (1979-2011), CQVIP (1989-2011), Chinese Biomedical Literature Database (1979-2011), Wanfang Database (1998-2011), EMbase (1900-2011) and PubMed (1966-2011). Results Sixteen papers on case-control study were included in this study, involving 818 non-smoking patients with lung cancer and 921 healthy controls. Meta-analysis showed that the risk of developing lung cancer was significantly higher in non-smoking Chinese with GSTM1 -deficit genotype than in those without GSTMl-deficit genotype (OR=1.65, 95%CI=1.34, 2.04). Egger's and Begg's analysis showed that the risk of developing lung cancer was 1.48-fold (95%CI=1.14, 1.91) and 2.03-fold (95%CI=1.42, 2.90) higher in Chinese of both South and North China with GSTMl-deficit genotype than that in controls. Conclusion The risk of developing lung cancer is significantly higher in non-smoking Chinese with GSTMl-deficit genotype.%目的 利用Meta 分析方法评价谷胱甘肽S- 转移酶M1(glutathione S-transferase M1,GSTM1) 基因多态性与中国人群非吸烟肺癌发病的相关性.方法 检索中国期刊全文数据库(1979-2011)、维普中文科技期刊数据库(1989-2011)、中国生物医学文献数据库(1979-2011)、万方数据库(1998-2011)、EMbase(1900-2011) 和PubMed (1966-2011) 数据库,收集有关中国人群GSTM1 基因多态性与非吸烟肺癌关系的研究.结果 共纳入16 篇文献对照研究,包括非吸烟肺癌患者818 例,对照组921 例.Meta 分析结果显示:GSTM1 缺失基因型的中国人群患非吸烟肺癌的风险明显增高(OR=1.65,95%CI=1.34,2.04).亚组分析发现,具有GSTM1 缺失基因型的中国南方和北方人群罹患非吸烟肺癌的风险分别为对照组的1.48 倍(95%CI=1.14,1.91) 和2.03 倍(95%CI=1.42,2.90).结论 GSTM1 缺失基因型使中国人群非吸烟肺癌的发病风险显著增加.