术前血清C反应蛋白水平对腹膜后恶性纤维组织细胞瘤患者预后的预测价值

摘要

Objective To analyze the relationship between serum preoperative C-reactive protein (CPR) level and the prognosis of retroperitoneal malignant fibrous histiocytoma (MFH).Methods Clinical pathological and prognostic data about 50 patients with retroperitoneal MFH in Chinese PLA General Hospital from March 2000 to March 2015 were collected.According to the CRP level,patients were divided into high CRP group (n=19) and normal CRP group (n=31).The differences in clinicopathological features and prognosis between the two groups were analyzed.Results Univariate analysis showed that CRP level (x 2=5.911,P=0.015),operation method (x 2=16.811,P=0.000) and tumor stage (x 2=4.741,P=0.037) were related to prognosis.The multivariate analysis showed that CRP level (HR=4.865,P=0.003),operation method (HR=4.546,P=0.002) and tumor stage (HR=2.4,P=0.031) were independent prognostic factors for prognosis of MFH.Conclusion Retroperitoneal MFH patients with high serum CRP level have poor prognosis.%目的 探讨术前血清C反应蛋白(C-reactive protein,CRP)与腹膜后恶性纤维组织细胞瘤(malignant fibrous histiocytoma,MFH)预后的相关性.方法 回顾性分析2000年3月-2015年3月解放军总医院收治的50例腹膜后MFH患者的临床和预后资料,根据CRP水平将其分为CRP高水平组(19例)和CRP正常水平组(31例),分析两组的临床特点及预后差异.结果 单因素分析显示术前CRP水平(x 2=5.911,P=0.015)、手术根治水平(x 2=16.811,P=0.000)及肿瘤分级(x2=4.741,P=0.037)与腹膜后MFH患者预后相关,多因素分析显示术前CRP水平(HR-4.865,P=0.003)、手术根治水平(HR=4.546,P=0.002)及肿瘤分级(HR=2.4,P=0.031)是腹膜后MFH预后的独立影响因素.结论 术前CRP水平高的腹膜后MFH患者预后差.