目的 观察玛咖及复方玛咖对更年期综合征患者相关症状、疲劳状态、抑郁和焦虑水平、激素水平及抗氧化指标的影响.方法 采用随机对照双盲实验,2016年2-4月解放军总医院门诊招募更年期综合征女性受试者80例,随机分为复方玛咖组(40例)、玛咖组(40例),分别口服复方玛咖(6片/d)、玛咖(7片/d),干预3个月后,比较两组之间及同组干预前后更年期自我综合评定结果、疲劳评定结果、PHQ-9抑郁症及GAD-7焦虑症评分、血清雌激素水平及抗氧化指标.结果 共73例受试者完成研究(复方玛咖组37例,玛咖组36例),失访率8.75％.与干预前比较,两组均能够提高记忆力、改善失眠、减轻泌尿系统症状及降低血清丙二醛水平(P均＜0.05);干预后组间比较,复方玛咖组较玛咖组在提高记忆力、改善失眠方面的效果更为明显(P均＜0.05).结论 口服玛咖及复方玛咖能够提高更年期女性记忆力,改善失眠,减轻泌尿系统症状,增强机体抗氧化能力.复方玛咖在提高记忆力方面的作用更加明显.%Objective To observe the effect of Maca or compound Maca on symptoms of menopause syndrome (as well as fatigue,depression and anxiety,hormone levels and antioxidant indexes).Methods This was a randomized controlled double-blind trial.Eighty subjects with menopausal syndrome were recruited and randomly assigned into compound Maca group (compound Maca,6 tablets/day,n=40) and Maca group (Maca,7 tablets/day,n=40).The intervention lasted for 3 months,and then the changes of Kupperman score,FS-14 score,PHQ-9 score and GAD-7 score,serum estrogen level and antioxidant index between two groups and self-contrast were compared.Results Seven subjects were lost to follow-up (8.75％),and the rest of subjects (compound Maca group,n=37;Maca group,n=36) were included in analysis.Comparison between pre-intervention and post-intervention revealed that Maca and compound Maca were both able to enhance memory,improve insomnia,alleviate symptoms of urinary system and reduce serum malondialdehyde (MDA) level (P ＜ 0.05 respectively);Compared with Maca group in post-intervention,compound Maca could improve memory and insomnia more significantly (P ＜ 0.05,respectively).Conclusion Oral supplement of Maca or compound Maca can improve memory and insomnia,alleviate symptoms of urinary system,and enhance the ability anfioxidation in the menopausal women,and the effect of compand Maca in improving memory function is more significant.
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