散发性Creutzfeldt-Jakob病脑脊液生物标记物的研究进展

摘要

The clinical manifestation in the early stage of sporadic Creutzfeldt-Jakob disease (sCJD) lacks of specificity, which may cause difficulty in the diagnosis and differential diagnosis of sCJD. Moreover, pathological examination is difficult to carry out because a brain biopsy or an examination of brain tissue can confirm sCJD only after death. So the specific cerebrospinal fluid biomarkers, imaging and electrophysiological examination will be the necessary means to diagnose sCJD. Among them, the detection of specific cerebrospinal fluid biomarkers is the most immediate, simple and acceptable way. In this paper, the specific cerebrospinal fluid biomarkers for sCJD in nearly ten years' literature are reviewed.%散发性Creutzfeldt-Jakob病的早期临床表现缺乏特异性,给其诊断及鉴别诊断带来困难,而病理确诊愈加难以实现,因为只有病人死后才能进行脑组织活检,因此特异性脑脊液生物学标记物、影像学表现及电生理检查日渐成为临床早期无创诊断散发性Creutzfeldt-Jakob病的必要手段,特异性脑脊液生物学标记物检测是用于诊断该病最为直接、简单、易于接受的方式.本文将针对散发性Creutzfeldt-Jakob病脑脊液生物学标记物近10年的研究进行综述.