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Design and synthesis of novel benzimidazoles and aminothiazoles as small molecule inhibitors of CDK5/p25

机译：新型苯并咪唑和氨基噻唑作为CDK5 / p25小分子抑制剂的设计与合成

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作者
Jain, Prashi;
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作者单位

Duquesne University;

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授予单位 Duquesne University;
学科
学位 Ph.D.
年度 2012
页码 304 p.
总页数 304
原文格式 PDF
正文语种 eng
中图分类
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1. Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. [J] . Jain P, Flaherty PT, Yi S, Bioorganic and medicinal chemistry . 2011,第1期

机译：设计，合成和测试一系列基于6-O联苯并咪唑的CDK5 / p25抑制剂。
2. Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)- thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors [J] . Malmstr?mJ., ViklundJ., SlivoC., Bioorganic and Medicinal Chemistry Letters . 2012,第18期

机译：4-（1,3-苯并噻唑-2-基）-噻吩-2-磺酰胺作为细胞周期蛋白依赖性激酶5（cdk5）/ p25抑制剂的合成及其构效关系
3. Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors [J] . Hussein Abdel Haleem M., Khames Ahmed A., El-Adasy Abu-Bakr A., RSC Advances . 2020,第50期

机译：新型2-氨基噻唑支架的设计，合成和生物学评价为磷酸二磷酸二氨基酯酶5型调节剂和COX-1 / COX-2抑制剂
4. Design, Synthesis, and Cytoprotective Effect of 2-Aminothiazole Analogues as Potent Poly(ADP-Ribose) Polymerase-1 Inhibitors [C] . Wen-Ting Zhang, Gang-Ying Chen, Yi-Jing Zhu, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：2-氨基噻唑类似物作为强力聚（ADP-核糖）聚合酶-1抑制剂的设计，合成和细胞保护作用
5. Design, Synthesis, and Biological Evaluation of Non-Symmetric Small Molecules as Inhibitors of Plasminogen Activator Inhibitor (PAI-1). [D] . Anumala, Himabindu. 2014

机译：非对称小分子作为纤溶酶原激活物抑制剂（PAI-1）的抑制剂的设计，合成和生物学评估。
6. Design Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors [O] . Wei Zhou, Wenjin Zhang, Yi Peng, 2020

机译：新型苯并咪唑-Chalcone杂交种的设计合成和抗肿瘤活性作为非间隙拓扑异构酶II催化抑制剂
7. Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation [O] . Menna-Allah Shalaby, Eman Dokla, Rabah Serya, 2019

机译：基于PBP2A抑制剂的新型吡唑和苯并咪唑的衍生物鉴定：设计，合成和生物学评估

Design and synthesis of novel benzimidazoles and aminothiazoles as small molecule inhibitors of CDK5/p25

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