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Targeting the Mutant JAK2 V617F Tyrosine Kinase by Small Molecules that Bind to its Pseudokinase Domain

机译：绑定到其假激酶结构域的小分子靶向突变的JAK2 V617F酪氨酸激酶。

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作者
Puleo, David Edward;
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作者单位

Yale University;

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授予单位 Yale University;
学科
学位 Ph.D.
年度 2018
页码 137 p.
总页数 137
原文格式 PDF
正文语种 eng
中图分类
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专利

1. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain [J] . McNally Randall, Li Qing, Li Kunhua, ACS Chemical Biology . 2019,第4期

机译：野生型和V617F突变体JAK2伪转基因酶结构域ATP位点配体的发现和结构表征
2. Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F [J] . Bandaranayake R.M., Ungureanu D., Shan Y., Nature structural & molecular biology . 2012,第8期

机译：JAK2假激酶结构域和致病性突变体V617F的晶体结构
3. The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains [J] . Arturo Sanz Sanz, Yashavanthi Niranjan, Henrik Hammaren, Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2014,第10期

机译：JH2域和SH2-JH2接头调节JAK2活性：野生型和V617F突变激酶域的详细动力学分析
4. Mixed-lineage kinase domain-like (MLKL) is a novel pseudokinase regulator of haematopoietic stem cell function, which modulates JAK2 signalling [C] . Murphy J.M., Tannahill G.M., Majewski I.J. Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：混合谱系激酶域样（MLK1）是一种新型纯化干细胞功能的伪转酶调节剂，其调节JAK2信号传导
5. Single chain antibody targeting of the ligand binding domain of the tyrosine kinase receptor anaplastic lymphoma kinase. [D] . Stylianou, Dora C. 2006

机译：单链抗体靶向酪氨酸激酶受体间变性淋巴瘤激酶的配体结合结构域。
6. Crystal structures of the Jak2 pseudokinase domain and the pathogenic mutant V617F [O] . Rajintha M. Bandaranayake, Daniela Ungureanu, Yibing Shan, -1

机译：在Jak2的假性域的晶体结构和致病突变V617F
7. Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F [O] . Rajintha M Bandaranayake, Daniela Ungureanu, Yibing Shan, 2012

机译：JAK2伪导体酶结构域的晶体结构和病原突变体V617F

Targeting the Mutant JAK2 V617F Tyrosine Kinase by Small Molecules that Bind to its Pseudokinase Domain

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