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Personal exposure and biomarkers among production welders and non-welders.

机译:生产焊工和非焊工之间的个人接触和生物标志物。

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摘要

Intro. A welding fume welding-related exposure assessment using various assessment methods was conducted to more thoroughly evaluate the impact of welding fume exposure.;Objectives. The objective of this study was to conduct personal exposure and biomonitoring on a group of production welders and non-welders in a large manufacturing facility. Personal exposures and biomarkers were compared between welders and non-welders.;Methods. Thirty-eight workers comprised of sixteen welders and 22 non-welders were sampled on a Monday. Welding fume metals along with passive NO2 and O3 samples were collected in the breathing zone of welders and non-welders. Personal metal fume samples were analyzed for a spectrum of metals using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Samples of blood, urine, exhaled air, and exhaled breath condensate were also collected before and after the work shift. These samples were used to investigate biomarkers of exposure and effect. Spirometry was also done before and after the work shift.;Results. Exposure concentrations of metal fumes, expressed as geometric means (GM) and geometric standard deviation (GSD). Concentrations were 474 (3.5) mug/m3 for welders and 60 (2.8) mug/m 3 for non-welders, and exposure concentrations of metal fumes were significantly higher in welders than in non-welders (p = 0.001). Welders were exposed to greater concentrations of NO2 (37ppb for welders, 23 ppb for non-welders) and O3 (7.3ppb for welders, 3.2 ppb for non-welders) than non-welders but the differences were not significant.;Conclusions. Exposure concentrations of metal fume differed significantly between welders and non-welders while concentrations of NO 2 and O3 did not. Non-welders experienced exposures to metals similar to those doing semi-automated stainless steel GTAW despite a curtain wall barrier separating welding and non-welding work areas. Metals biomarkers in blood and urine were not specifically associated with welders as a group and welders exposed to welding fume metals at the highest levels did not show elevated metals in blood or urine. Exposures did not appear to induce elevated levels of biomarkers of effect in the blood of welders compared to non-welders. Welders showed decreases in pulmonary function that may be an indicator of the onset of small airway disease.
机译:介绍。使用各种评估方法进行了与焊接油烟焊接相关的暴露评估,以更彻底地评估焊接油烟暴露的影响。这项研究的目的是对大型制造工厂中的一组生产焊工和非焊工进行个人暴露和生物监控。比较焊工和非焊工的个人暴露和生物标志物。星期一抽样了38名工人,包括16名焊工和22名非焊工。焊接烟气金属以及被动式NO2和O3样品均收集在焊工和非焊工的呼吸区域中。使用电感耦合等离子体质谱法(ICP-MS)分析个人金属烟雾样品的金属光谱。在轮班之前和之后,还采集了血液,尿液,呼出的空气和呼出的冷凝水的样本。这些样品用于研究暴露和效应的生物标志物。轮班前后也进行肺活量测定。金属烟雾的暴露浓度,以几何平均值(GM)和几何标准偏差(GSD)表示。焊工的浓度为474(3.5)杯/立方米,非焊工的浓度为60(2.8)杯/立方米,焊工的金属烟气浓度显着高于非焊工(p = 0.001)。焊工比非焊工暴露的NO2(焊工37ppb,非焊工23 ppb)和O3(焊工7.3ppb,非焊工3.2 ppb)的浓度更高,但差异不显着。焊工与非焊工的金属烟气暴露浓度差异显着,而NO 2和O3的浓度则无差异。尽管幕墙隔离了焊接和非焊接工作区域,但非焊接人员所经历的金属暴露与半自动GTAW相似。血液和尿液中的金属生物标志物与焊工并没有特别的关联,并且暴露于最高浓度的焊接烟气中的焊工并未显示血液或尿液中的金属含量升高。与非焊接者相比,暴露似乎没有在焊接者血液中诱导升高的作用生物标志物水平。焊工显示肺功能下降,这可能是小气道疾病发作的指标。

著录项

  • 作者

    Schoonover, Todd M.;

  • 作者单位

    University of Illinois at Chicago.;

  • 授予单位 University of Illinois at Chicago.;
  • 学科 Health Sciences Occupational Health and Safety.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 209 p.
  • 总页数 209
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遥感技术;
  • 关键词

  • 入库时间 2022-08-17 11:38:20

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