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Investigation of the local anesthetic binding site in voltage-gated sodium channels using cholic acid-, alpha-hydroxyamide-, and hydantoin-based analogs

机译：使用基于胆酸，乙羟胺和乙内酰脲的类似物研究电压门控钠通道中的局部麻醉药结合位点

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作者
Davis, Gary Cornelius;
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作者单位

University of Virginia;

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授予单位 University of Virginia;
学科
学位 Ph.D.
年度 2008
页码 168 p.
总页数 168
原文格式 PDF
正文语种 eng
中图分类
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专利

1. Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding [J] . Scheib H, McLay I, Guex N, Journal of molecular modeling . 2006,第6期

机译：对封闭，开放和快速灭活构象中的电压门控钠通道的孔结构进行建模，揭示了位点1毒素和局部麻醉剂结合的细节
2. Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. [J] . Lipkind GM, Fozzard HA Molecular pharmacology. . 2005,第6期

机译：电压门控钠通道与局麻药结合的分子模型。
3. Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation. [J] . Bai CX, Glaaser IW, Sawanobori T, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2003,第1期

机译：钠通道IVS6上的局部麻醉剂结合位点参与快速和缓慢失活。
4. Single-channel properties of voltage-gated potassium and sodium channels [C] . Ozturk, E., Ozer, . 2005

机译：电压门控钾钠通道的单通道特性
5. Modulation of voltage-gated potassium and sodium channels by halogenated general anesthetics: Structural and biophysical insights into the mechanisms of action. [D] . Barber, Annika F. 2013

机译：卤代全身麻醉药对电压门控钾离子和钠离子通道的调节：作用机理的结构和生物物理见解。
6. Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine [O] . Jean-François Desaphy, Antonella Dipalma, Teresa Costanza, 2012

机译：使用美西律的羟化类似物对电压门控钠通道内的局部麻醉受体的分子洞察
7. Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine [O] . Desaphy, Jean-François, Dipalma, Antonella, Costanza, Teresa, 2012

机译：使用美西律的羟化类似物对电压门控钠通道内的局部麻醉受体的分子洞察

Investigation of the local anesthetic binding site in voltage-gated sodium channels using cholic acid-, alpha-hydroxyamide-, and hydantoin-based analogs

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