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A Dependent Competing Risks Model

机译:相依竞争风险模型

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摘要

The competing risks model considers the setting where subjects or units are exposed to multiple risks one of which may eventually cause the occurrence of the event, such as failure or recurrence or death. There is a substantial literature on identifiability and inference in both parametric and nonparametric models for competing risks. In this dissertation, we propose a parametric model for dependent competing risks that can be motivated by a frailty approach as well as by a copula approach. We establish identifiability conditions for this proposed model. We also consider competing risks regression framework and establish identifiability and methods for statistical inference in this framework. This proposed model has been further extended to analysis of semi-competing data while we again establish identifiability and statistical inference. The proposed models have been illustrated in extensive simulation studies and we apply these models to analyze competing risks data from a Tamoxifen trial on breast cancer patients and to analyze semi-competing risks data from a trial on tuberculous pericarditis collected in eight countries in Africa.
机译:竞争风险模型考虑了主体或单位面临多种风险的环境,其中一种风险最终可能导致事件的发生,例如失败,复发或死亡。在竞争风险的参数模型和非参数模型中,都有大量关于可识别性和推理的文献。在本文中,我们提出了一种基于相关竞争风险的参数模型,该模型可以通过脆弱方法和copula方法来激发。我们为此拟议模型建立了可识别性条件。我们还考虑竞争风险回归框架,并在此框架中建立可识别性和统计推断方法。该提议的模型已进一步扩展到半竞争数据的分析,同时我们再次建立了可识别性和统计推断。在广泛的模拟研究中对拟议的模型进行了说明,我们将这些模型用于分析来自Tamoxifen乳腺癌患者试验的竞争风险数据,以及分析来自非洲八个国家的结核性心包炎试验的半竞争风险数据。

著录项

  • 作者

    Wang, Yiqing.;

  • 作者单位

    Northern Illinois University.;

  • 授予单位 Northern Illinois University.;
  • 学科 Statistics.;Biostatistics.;Systems science.
  • 学位 Ph.D.
  • 年度 2018
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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