Scope and Method of Study. Measurement of the mechanical properties of guinea pig tympanic membrane (TM) with fringe projection and simulation. Fringe projection technique was used to provide optic access for measurement of the volume displacement of TM under different pressure levels. FEM model with hyperelastic constitute law was built to simulate the experimental procedure. Experimental data and simulation result were fitted to obtain the hyperelastic parameters of guinea pig TM.;Findings and Conclusions. Hardening effects was observed through pressure-volume displacement curve. The stress-strain curve plotted based on the estimated mechanical properties was also reflect such phenomenon. Comparison between the positive and negative pressure loading from middle ear cavity indicate that, such hardening effect is stronger as negative pressure applied.;The observation of the section profile of 3-D surface reconstruction of TM with Fringe projection technique shows that, the displacement around umbo is asymmetric. It means that the malleus tend to rotate rather than translate at high pressure level.;The experimental design was compared with other research group. Full-field mechanical properties measured with the designed experiment were validated by comparison to existed data in literature.
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