BioExpress: An Integrated RNA-seq Derived Gene Expression Database For Pan-cancer Analysis.

摘要

BioExpress is a gene expression and cancer association database where the expression levels are mapped to genes using high-quality RNA-seq data obtained from TCGA, ICGC, Expression Atlas and publications. The BioExpress database includes expression data from 23 cancer types, 6415 patients, 17,469 genes with 9612 of them differentially expressed in tumors. All cancer types are mapped to Disease Ontology terms to facilitate pan-cancer analysis. All genes are linked to BioMuta, a comprehensive cancer related non-synonymous single-nucleotide variation (nsSNV) database. BioMuta and BioExpress together provide a detailed view of the expression and mutations of genes in cancer and therefore together can be used for pan-cancer studies. The BioExpress database is easily searched using HGNC gene symbol, UniProtKB accession, protein accession or by cancer type with significance filters. This interface and downloadable files enables straightforward retrieval and display of a broad set of cancer-related genes. Access: http://hive.biochemistry.gwu.edu/tools/bioexpress.