Health issues related to the management of antineoplastic drugs.

摘要

Occupational exposures to antineoplastic drugs in clinical settings can take place through inhalation, dermal absorption, ingestion and injection. The objective of this study was to explore surface (wipe) sampling as a method to determine if surfaces are contaminated by antineoplastic drugs. Additionally, a compliance assessment, based on professional guidelines, was conducted on all areas of the antineoplastic drug life cycle within a hospital to determine areas where policy and practices are to be enhanced. Surface (wipe) sample results indicated surface contamination to drugs in pharmacy floors, infusion chairs, bathroom floors and the exterior surfaces of antineoplastic waste containers. The compliance assessment indicated lack of sound practices during drug preparation and administration. The results of this study indicated that some surfaces throughout the outpatient oncology department are being contaminated by antineoplastic drugs, which might lead to unacceptable exposures.