Cytotoxic constituents of three South American and Indonesian medicinal plants.

摘要

Bioactivity-guided fractionation of a chloroform extract of the aerial parts of Baccharis articulata (Lam.) Pers. has led to the isolation of two known compounds that were significantly active against the P-388 lymphocytic leukemia cell line, namely, apigenin and methyl-3-(3,4-dihydroxyphenyl)-2-propenoate. Also obtained were five inactive compounds, comprising three new compounds, 7-oxo-8;The potently sweet Baccharis gaudichaudiana constituent, gaudichaudioside A, was not detected in B. articulata extracts. An aqueous methanol extract of B. articulata was found to be bitter rather than sweet, which was determined as being due, in part, to the presence of 7-oxo-16,19-dihydroxy-3,4-dehydro-ent-clerodan-15,20-dicarboxy-dilactone, a bitter-tasting substance.;Three new compounds, 2-hydroxy-5-butoxyphenylacetic acid, 2;Activity-guided fractionation of the methanol extract of Fibraurea chloroleuca Miers resulted in the isolation of one major compound, berberine, which in the form of its chloride salt was observed to demonstrate significant cytotoxic activity for P-388 cells (ED