Studies to increase separation selectivity in capillary electrophoretic chiral separations using beta-cyclodextrin-containing polymers.

摘要

A mathematical model that describes the separation selectivity for chiral compounds in capillary electrophoresis predicts that selectivity will increase for Type II and III separations, when the ionic mobility of the enantiomer:chiral resolving agent complexes is decreased by, for example, bonding the chiral resolving agent to a polymer, or entrapping the chiral resolving agent in the pores of a crosslinked gel or a linear polymer network. In this work, ;Crosslinked polyacrylamide gels were synthesized by polymerizing ac-;MAC was copolymerized with acrylamide to yield MAC:acrylamide copolymers (MW 52,000). The ionic mobility of the homatropine enantiomer: