Studies on antifungal and antitumor fungal metabolites: Isolation, characterization and applications.

摘要

usarium lateritium is a natural antagonist of the serious plant pathogen Eutypa armeniacae which is associated with sapwood necrosis. Two novel biologically active compounds, 2(1-hydroxyethyl)-4(3H)quinazolinone and 2-acetyl-4(3H)-quinazolinone, and three antifungal metabolites, the enniatins B, ;In addition, the metabolite mixture produced by a Trichoderma fungus was shown to exhibit strong cytotoxic activity against murine leukemia cells and human solid tumor cells. A novel