Signals in DNA that affect nucleosome alignment and gene regulation.

摘要

ukaryotic DNA is packaged into chromatin which contains periodic arrays of nucleosomes. The nucleosome arrays reflect or influence the higher-order chromatin structure and function. Despite their importance in the higher-order chromatin structure and gene regulation, it is unclear how nucleosome arrays are formed.;Using an in vitro chromatin assembly system, we first investigated how a shortened nucleosome repeat arises specifically on