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Precision sequence-specific cleavage of nucleic acids by minor-groove directed metal binding ligands linked through N-2 of deoxyguanosine.

机译：通过通过脱氧鸟苷的N-2连接的小沟定向金属结合配体精确切割核酸的序列特异性。

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1,10-Phenanthroline was covalently linked from its 2-position to the N;In the presence of Fe(II), oxygen, and dithiothreitol (25

机译：1,10-菲咯啉从其2位与N共价连接;在Fe（II），氧和二硫苏糖醇存在下（25

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作者
Gerry, Norman Phillip.;
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作者单位

Purdue University.;

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授予单位 Purdue University.;
学科 Organic chemistry.;Biochemistry.
学位 Ph.D.
年度 1996
页码 145 p.
总页数 145
原文格式 PDF
正文语种 eng
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专利

1. Probing binding preferences of DNA and RNA: Backbone chirality of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids to differentiate DNA versus RNA selective binding [J] . Gokhale S.S., Gogoi K., Kumar V.A. The Journal of Organic Chemistry . 2010,第21期

机译：探索DNA和RNA的结合偏好：硫代乙酰氨基连接的核酸和异硫代乙酰氨基连接的核酸的骨架手性可区分DNA与RNA选择性结合
2. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins [J] . ThomasM.P., WhangboJ., McCrossanG., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2014,第11期

机译：白细胞蛋白酶与核酸的结合促进了核酸结合蛋白的核定位和裂解
3. Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins [J] . Marshall P. Thomas, Jennifer Whangbo, Geoffrey McCrossan, The journal of immunology . 2014,第11期

机译：白细胞蛋白酶与核酸的结合促进了核结合和核酸结合蛋白的裂解。
4. Sequence-Specific Cleavage of DNA by Peptide Nucleic Acids Conjugated with Metal Complexes [C] . Toru Sugiyama, Keiko Ninomiya, Yasutada Imamura Japanese peptide symposium . 2010

机译：用金属络合物缀合的肽核酸的DNA序列特异性切割
5. Evaluation of the sequence-specific DNA hybridization and cleavage capabilities of peptide nucleic acid-titanium dioxide nanoconjugates. [D] . Brown, Eric Michael Bratsolias. 2009

机译：肽核酸-二氧化钛纳米偶联物的序列特异性DNA杂交和切割能力的评估。
6. Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins [O] . Marshall P. Thomas, Jennifer Whangbo, Geoffrey McCrossan, -1

机译：白细胞蛋白酶与核酸的结合促进了核结合和核酸结合蛋白的裂解。
7. The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity. [O] . Bayle, J H, Elenbaas, B, Levine, A J 1995

机译：p53蛋白的羧基末端结构域通过其非特异性核酸结合活性来调节序列特异性DNA结合。

Precision sequence-specific cleavage of nucleic acids by minor-groove directed metal binding ligands linked through N-2 of deoxyguanosine.

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