首页> 外文学位 >Comparative risk analysis of toxic release inventory data for carcinogens: Does quantity reduction necessarily indicate less risk? A Michigan case study.
【24h】

Comparative risk analysis of toxic release inventory data for carcinogens: Does quantity reduction necessarily indicate less risk? A Michigan case study.

机译:致癌物毒性释放清单数据的比较风险分析:数量减少是否必然表明风险较小?密歇根州的案例研究。

获取原文
获取原文并翻译 | 示例

摘要

In recognition of the disastrous effects of the accidental release by industry of toxic chemicals around the globe, the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) was enacted. The EPCRA requires owners and operators of manufacturing facilities to submit reports on toxic chemical storage and release. One purpose of the EPCRA is to decrease total quantities of toxic chemicals and to provide local citizenry with the information necessary to protect themselves from the hazards presented by toxic chemicals.;Fundamental principles of toxicology illustrate that a direct correlation between quantity and risk, without consideration of other critical factors, does not necessarily exist. Therefore, a reduction in chemical quantity may not correspond to a decrease in the potential risk posed by that chemical. Recognition of this concept indicates that factors other than quantity must be used in determining whether the efforts to decrease toxic chemical quantities are directed appropriately.;Using Michigan as a case study, the dissertation focuses on specific carcinogens and extracts chemical data for reporting years 1987 through 1994. A hazard valuation algorithm, that integrates quantities with known toxicity values and accepted exposure assumptions to arrive at an estimated "hazard value," is applied to the Michigan data for the specific carcinogens. Evaluation of the correlation between the total quantities reported under the EPCRA and the total hazard values as calculated by the algorithm illustrates the EPCR's limitations for both evaluating toxic chemical data and assessing whether the efforts to decrease toxic chemical quantities are directed appropriately.;It is the thesis of this dissertation that analysis of the EPCRA toxic chemical data, using total quantity as the only analysis parameter, is not useful in assessing whether efforts to decrease toxic chemical quantities are directed appropriately.;Under the EPCRA, toxic chemical data is presented in quantities, without the incorporation of critical factors such as toxicity and exposure. Presenting data in this format is inaccurate and misleading and does not allow the average citizen to assess potential risk presented by the toxic chemicals. Further, with data presented in this format, accurate assessment of efforts to decrease total toxic chemicals is difficult.
机译:认识到全球工业意外释放有毒化学品的灾难性后果,颁布了1986年《紧急计划和社区知情权法案》(EPCRA)。 EPCRA要求制造设施的所有者和经营者提交有关有毒化学品存储和释放的报告。 EPCRA的目的之一是减少有毒化学物质的总量,并为当地公民提供保护自己免受有毒化学物质危害的必要信息。;毒理学的基本原理表明,数量和风险之间存在直接关联,无需考虑其他关键因素,不一定存在。因此,化学药品数量的减少可能并不对应于该化学药品带来的潜在风险的减少。对这一概念的认识表明,在确定是否有针对性地减少毒性化学物质的努力时,必须使用数量以外的其他因素。以密歇根州为例,本文着重研究特定的致癌物质,并提取1987年至2003年的化学数据。 1994年。一种危害评估算法,将具有已知毒性值的数量与可接受的暴露假设相结合,以得出估计的“危害值”,该算法应用于特定致癌物的密歇根州数据中。评估EPCRA所报告的总量与算法计算出的总危害值之间的相关性,说明了EPCR在评估有毒化学数据和评估减少有毒化学物质的努力是否得到适当指导方面的局限性。本文的结论是,以总量作为唯一的分析参数对EPCRA的有毒化学数据进行分析,对于评估是否有针对性地减少有毒化学物质的措施是否正确无益。 ,而没有纳入毒性和暴露等关键因素。以这种格式显示数据是不准确和误导的,并且不允许普通市民评估有毒化学物质带来的潜在风险。此外,以这种格式显示的数据很难准确评估减少总有毒化学品的工作量。

著录项

  • 作者单位

    Michigan State University.;

  • 授予单位 Michigan State University.;
  • 学科 Health Sciences Toxicology.;Law.;Environmental Sciences.
  • 学位 Ph.D.
  • 年度 1996
  • 页码 158 p.
  • 总页数 158
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号