Characterization of human plasminogen: Genetic and conservative mutations that affect proteolytic activity.

摘要

lasminogen is a serine protease with trypsin-like specificity. It contains a regulatory domain, which is comprised of an activation peptide and five homologous kringle domains, and a protease domain. Within both of these domains have been found abnormal variants that result in altered proteolytic activity of plasmin. Recombinant proteins containing the identified mutations as well as a few others have been expressed in the baculovirus-infected insect cell system. Those mutations identified in the genes of patients include: