首页> 外文学位 >The effects of water on camphorsulfonic acid doped polyaniline and the use of this chiral conjugated polymer for the enantiorecognition of L-phenylalanine.
【24h】

The effects of water on camphorsulfonic acid doped polyaniline and the use of this chiral conjugated polymer for the enantiorecognition of L-phenylalanine.

机译:水对樟脑磺酸掺杂的聚苯胺的影响以及该手性共轭聚合物对L-苯丙氨酸的对映体识别的用途。

获取原文
获取原文并翻译 | 示例

摘要

Polyaniline is a conjugated polymer that can be doped from an insulating form to a conducting form with a strong acid. Polyaniline doped with one of the enantiomers of camphorsulfonic acid becomes chiral and can be characterized with circular dichroism. This chiral form of polyaniline is significant because it is the first example of an achiral polymer becoming chiral via a doping process.; When studying this chiral form of polyaniline, we observed a strange phenomenon when polyaniline is exposed to water prior to doping. The chirality as viewed with circular dichroism can be inverted depending upon the water content of the powder. This result is significant in that it takes us one step closer to fully characterizing this chiral polymer system and also helps clarify conflicting observations reported in past literature. Enclosed are the studies of this phenomenon along with experiments that attempt to explain this odd and unexpected behavior.; The mechanism for chiral induction in polyaniline via doping with camphorsulfonic acid has yet to be elucidated. Here, studies are presented to discern whether or not the doping molecules induce chirality upon the polyaniline backbone via a direct contact or nucleation mechanism. The former method entails each dopant exerting its own influence upon the chirality of the polymer while the latter supposes that only a few dopants dictate chirality. Our preliminary results indicate that the induction of chirality is due to nucleation.; Camphorsulfonic acid doped polyaniline is hoped to be used as a new material for the chiral separation of pharmaceuticals and other chiral molecules. There is a great need for the chiral separation of drugs because different enantiomers of the same drug can have very different effects upon the human body. Additionally, most of the materials presently used in chiral separations are costly and not very effective. Within this dissertation, evidence will be presented for the enantiorecognition of the amino acid L-phenylalanine over its enantiomer D-phenylalanine by this chiral system. These studies are the first of their kind and support the possibility of using chiral polyaniline for chiral separations.
机译:聚苯胺是一种共轭聚合物,可以用强酸从绝缘形式掺杂成导电形式。掺杂有樟脑磺酸对映异构体之一的聚苯胺变成手性的,并具有圆二色性。聚苯胺的手性形式是重要的,因为它是非手性聚合物通过掺杂过程变为手性的第一个例子。在研究这种手性形式的聚苯胺时,我们发现在掺杂之前将聚苯胺暴露于水会产生一个奇怪的现象。圆二色性观察到的手性可以根据粉末的水含量而反转。这一结果意义重大,因为它使我们更能全面表征该手性聚合物体系,并且有助于澄清过去文献中报道的相互矛盾的观察结果。随函附上对该现象的研究以及尝试解释这种奇怪和意外行为的实验。尚没有阐明通过掺杂樟脑磺酸在聚苯胺中手性诱导的机理。在此,提出了研究以识别掺杂分子是否通过直接接触或成核机制在聚苯胺主链上诱导手性。前一种方法要求每种掺杂剂对聚合物的手性施加其自身的影响,而后一种方法则假定只有少数掺杂剂决定了手性。我们的初步结果表明手性的诱导是由于成核。樟脑磺酸掺杂的聚苯胺有望用作药物和其他手性分子手性分离的新材料。迫切需要药物的手性分离,因为同一药物的不同对映异构体对人体的影响可能大不相同。另外,目前在手性分离中使用的大多数材料是昂贵的并且不是很有效。在本论文中,将提供通过该手性体系对氨基酸L-苯丙氨酸对其对映体D-苯丙氨酸进行对映体识别的证据。这些研究尚属首次,它们支持使用手性聚苯胺进行手性分离的可能性。

著录项

  • 作者

    Egan, Veronica Marjorie.;

  • 作者单位

    University of California, Los Angeles.;

  • 授予单位 University of California, Los Angeles.;
  • 学科 Chemistry Polymer.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 107 p.
  • 总页数 107
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化学(高聚物);
  • 关键词

  • 入库时间 2022-08-17 11:47:19

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号