The measurement of progression of diabetic retinopathy.

摘要

Diabetic retinopathy is a complication of diabetes and the leading cause of blindness. Many different progression definitions are used in the literature and there is not yet a “gold standard” for defining progression.; This analysis compares different definitions of progression to determine whether differences exist in the prediction of risk factors of the disease. Comparisons of the results were made to previous analysis. The data is from the Southern Alberta Study of Diabetic Retinopathy, which is a 3-year population-based follow-up study.; Generalized additive modeling and logistic analyses were used. Modeling of the definitions yielded similar results for all models and they were consistent with the literature. Blood glucose, blood pressure, albumin excretion rate and baseline retinopathy status were all present as risk factors in the different models. The definitions differed slightly in the interactions present and AER, native status and hypertension were risk factors not present in all models.