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Neural circuitry underlying expression of Fos-like immunoreactivity in intermediate nucleus of the solitary tract following expression of taste aversion learning.

机译:在味觉厌恶学习的表达后,在孤立道中核中Fos样免疫反应性表达的潜在神经回路。

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摘要

Taste aversion learning results from the association between a novel, palatable taste and transient malaise such that re-exposure to the taste results in the animal displaying rejection behaviors. Expression of a conditioned taste aversion (CTA) is also associated with the expression of fos -like immunoreactivity (FLI) in the medial region of the intermediate nucleus of the solitary tract (iNTS) following subsequent exposure to a taste that has been previously paired with LiCl. This cellular marker of activation has been used to identify brain structures involved in CTA. Recent findings indicate that different conditioning methods may involve different neural circuits. Amygdala is necessary for both behavioral expression of CTA and FLI when an intraoral infusion (I/O) of the tastant is used at the time of conditioning. However, amygdala is not necessary for the behavioral expression of CTA when bottle conditioning is used. Therefore, the first aim of this dissertation was to determine if expression of FLI following CTA was dependent upon conditioning method. The second and third aims characterize the efferent and afferent projections of CTA-induced FLI cells to obtain a better understanding of the neural circuitry underlying taste aversion learning.; The results of the first study showed that I/O and bottle methods generated aversions that were comparable, when judged by the behavioral response of solution rejection. However, elevations in FLI were seen only in animals conditioned with the I/O method. Furthermore, expression of FLI was localized to the parvicellular subdivision of iNTS.; The second and third studies used several techniques to characterize these projections including anterograde and retrograde tract tracing, double labeling for retrograde tract tracer and FLI, and lesions. FLI cells in iNTS receive direct projections from amygdala, paraventricular hypothalamus and lateral hypothalamus. The targets of nearly 80% of FLI cells were accounted for, of these, over half of these FLI cells project to structures in the pons and forebrain while the remaining cells project locally within the medulla. Finally, these cells are not necessary for the oromotor rejection responses associated with expression of taste aversion learning.
机译:厌味的学习源于新颖,可口的味觉与短暂不适之间的联系,因此,再次暴露于味觉会导致动物表现出排斥行为。条件性味觉厌恶(CTA)的表达还与随后暴露于结直肠癌的孤立道中核(iNTS)中间区域的 fos 样免疫反应性(FLI)的表达有关。以前与LiCl配对的口味。这种激活的细胞标记已被用于识别CTA中涉及的大脑结构。最近的发现表明,不同的调节方法可能涉及不同的神经回路。当在调理时使用促味剂的口内输注(I / O)时,杏仁核对于CTA和FLI的行为表达都是必需的。但是,使用瓶装调理剂时杏仁核对于CTA的行为表达不是必需的。因此,本文的首要目标是确定CTA后FLI的表达是否依赖于调节方法。 第二第三目标表征CTA诱导的FLI细胞的传出和传出预测,以更好地理解味觉厌恶学习的神经回路。第一项研究的结果表明,根据溶液排斥的行为响应判断,I / O和瓶装方法产生的厌恶程度可比。但是,仅在使用I / O方法适应的动物中才能看到FLI升高。此外,FLI的表达定位于iNTS的小细胞细分。第二项和第三项研究使用了几种技术来表征这些预测,包括顺行和逆行道描记,逆行道示踪剂和FLI的双重标记以及病变。 iNTS中的FLI细胞从杏仁核,脑室下丘脑和下丘脑外侧直接投射。占了将近80%的FLI细胞的靶标,其中这些FLI细胞的一半以上投射到脑桥和前脑中的结构,而其余细胞则局部投射在延髓内。最后,这些细胞对于与味觉厌恶学习的表达有关的口运动排斥反应不是必需的。

著录项

  • 作者

    Spray, Kristina Jean.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Biology Neuroscience.; Psychology Physiological.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 135 p.
  • 总页数 135
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;生理心理学;
  • 关键词

  • 入库时间 2022-08-17 11:46:25

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