Genetic Screening Practices at Oocyte Donation Programs.

摘要

The American College of Obstetricians and Gynecolegists (ACOG) and the American College of Medical Genetics (ACMG) publish general population and ethnicity-based guidelines for genetic screening practices in the reproductive setting. Additionally, the American Society for Reproductive Medicine (ASRM) publishes guidelines for gamete and embryo donation, pooling guidelines from a number of sources, including ACOG, but they are less specific than ACOG or ACMG. This study aimed to determine what of those guidelines, additional genetic testing options, and other comprehensive screening techniques were being implemented at oocyte donation programs nationwide. Cystic fibrosis carrier screening is the only testing regularly implemented at 97% of programs. Genetics professionals and genetic counseling services are inconsistently involved in the genetic screening of gamete donors. In conclusion, ASRM guidelines should be updated to specify appropriate screening tests based on ACOG and ACMG guidelines, and genetic counselors are perfectly suited to translate those guidelines to practice.