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Development of integrated dielectric elastomer actuators (IDEAs): Trending towards smarter and smaller soft microfluidic systems.

机译:集成介电弹性体致动器(IDEA)的开发:朝着更智能,更小型的软微流体系统发展的趋势。

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摘要

During the last five years, great advancements in microfluidics have been achieved with the development of "sample-in-answer-out" systems. Such systems have begun to realize the true potential of analytical miniaturization since the concept of the "micro-Total Analysis System" was first envisioned. These systems are characterized by the elegant integration of multiple fluid-handling channel architectures that enable serial execution of sample preparation, separation and detection techniques on a single device. While miniaturization and portability are often identified as key advantages for microfluidics, these highly integrated systems are heavily reliant upon large off-chip equipment, i.e. the microchip is often tethered to the laboratory via multiple syringe pumps, vacuum pumps, solenoid valves, gas cylinders and high voltage power supplies.;In this dissertation, a procedure for the facile integration of dielectric elastomer (DE) actuators (called IDEAs) onto microfluidic devices is described. Poly(dimethylsiloxane) (PDMS) is commonly used as a microchip substrate because it is cheap and easy to fabricate, mechanically robust and optically transparent. The operation of an IDEA exploits the ability of PDMS to behave as a smart material and deform in the presence of an electric field. In Chapter 2, the fabrication of IDEA units on a standard microchip electrophoresis device is described. IDEA-derived injections were used to evaluate the physical performance of this novel actuator configuration.;In Chapter 3, the analytical merits of IDEA-derived injections were evaluated. Sampling bias caused by electokinetic injection techniques has been problematic for conventional microchip electrophoresis systems due to the lack of fluid access. The hydrodynamic injections created by IDEA operation were found to be highly reproducible, efficient, and possess a negligible degree of sampling bias. In Chapter 4, the spatial characteristics of microchannel deformation due to IDEA actuation have been investigated using fluorescence microscopy. It was determined that the DE compresses more along the edge of the channel than in the middle of the channel. This information can be used to design a new generation of more efficient IDEAs.
机译:在过去的五年中,随着“进样出”系统的发展,微流体技术取得了长足的进步。自从最初设想“微观总分析系统”的概念以来,这种系统就开始实现分析微型化的真正潜力。这些系统的特点是多种流体处理通道架构的完美集成,可在单个设备上串行执行样品制备,分离和检测技术。虽然小型化和便携性通常被认为是微流体技术的主要优势,但这些高度集成的系统严重依赖大型片外设备,即,微芯片通常通过多个注射泵,真空泵,电磁阀,气瓶和在本文中,描述了将介电弹性体(DE)执行器(称为IDEA)轻松集成到微流体设备上的过程。聚(二甲基硅氧烷)(PDMS)通常用作微芯片基板,因为它便宜且易于制造,机械强度高且光学透明。 IDEA的操作利用了PDMS的功能,使其表现为智能材料,并在存在电场的情况下变形。在第二章中,描述了在标准微芯片电泳设备上IDEA单元的制造。使用IDEA衍生的进样来评估这种新型执行器配置的物理性能。在第3章中,评估了IDEA衍生的进样的分析优点。由于缺乏流体通道,对于常规的微芯片电泳系统,由电动注入技术引起的采样偏差一直是个问题。发现由IDEA操作产生的流体动力注入具有高度可重复性,高效且采样偏差程度可忽略不计。在第4章中,已经使用荧光显微镜研究了由IDEA驱动引起的微通道变形的空间特征。已确定DE沿通道边缘的压缩比在通道中间的压缩更大。此信息可用于设计新一代更高效的IDEA。

著录项

  • 作者

    Price, Alexander K.;

  • 作者单位

    Kansas State University.;

  • 授予单位 Kansas State University.;
  • 学科 Chemistry General.;Chemistry Analytical.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 125 p.
  • 总页数 125
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:37:25

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