Knowledge synthesis in the biomedical literature: Nordihydroguaiaretic acid and breast cancer.

摘要

This dissertation refines knowledge synthesis from publicly accessible databases, based on the model of D. R. Swanson. Knowledge synthesis endeavors bring together two or more noninteractive literatures to create combinatorial research data on a specific topic. In this endeavor the biomedical literature was searched on the anti-neoplastic agent nordihydroguaiaretic acid (NDGA) for its potential role as a functional food in the chemoprevention of breast cancer. Bibliometric cocitation was utilized to identify complementary but non-interactive literatures in the disciplines of biomedicine and dietary science.; The continuing specialization and fragmentation of the cancer literature degenerates the potential usefulness of cross-disciplinary research and information. As the biomedical sciences become more specialized the potential increases for isolation of discoveries and for failures to connect science to the needs of the people. Within the information science discipline several techniques are available to bridge the isolation between discoveries recorded in different sets of literatures. Electronic database searching with combinatorial keyword entries, syllogistic modeling and bibliometric author cocitation analysis are the principle techniques applied in this endeavor.; The research questions are addressed to the absence or presence of human in vivo research on breast cancer with the potentially chemopreventative functional food NDGA. Utilizing a syllogistic model the literatures of functional foods, nordihydroguaiaretic acid and breast cancer were searched with designated combinatorial keywords. The documents retrieved were subjected to author cocitation analysis to demonstrate disjointness or connectivity of the two complementary literatures. The results demonstrated a possible preventative relationship between breast cancer in women and nordihydroguaiaretic acid, a phytochemical antioxidant and potential functional food. The results of the study are consistent with D. R. Swanson's pioneering work in knowledge synthesis. Swanson's methods can be used to identify non-interactive, disjoint literatures. Continuing support for his techniques has been demonstrated.