Basic Study on Degradation of nHAP-PLGA-Collagen---A Novel Biopolymer.

摘要

Bone tissue engineering is a rapidly developing field of interest. Bone scaffold materials have several applications of great importance including the fostering of healthy bone tissue and the repair of bone defects both in-vivo and in-vitro. Ideal scaffolds should be biocompatible, biodegradable, and promote cellular interactions and tissue development, and possess proper mechanical and physical properties. nHAP-PLGA-Collagen is a novel synthesized block-polymer which has proved biocompatibility and mechanical properties. This thesis is focused on the degradation-controlling to fulfill the requirement of bone reconstruction and afterward digestion. The research focuses on internal and external factors which have effects on degradation time of nHAP-PLGA-Collagen. Internal factors include monomer ratio of D,L-lactide and glycolide monomers, porosity, and macro construction, which can modify the polymer. And external factors are temperature and pH impact the degradation of storage and during bone forming. In this thesis, nHAP-PLGA-Collagen block polymer has been characterized and been proven to have properties accounting for a bone scaffold material, including degradation adaptability.