New method for the preparation of 1,2,3 viciual tricarbonyl systems as potential enzyme inhibitors.

摘要

Antibiotic drug are one of the most important instruments used in chemotherapy treatments. For a long time, beta-lactams were used as antibiotics to control the bacterial infections. However, the high consumption of beta-lactams have caused the bacteria to develop tolerance, through the production of beta-lactamases, an enzyme that neutralizes the effect of b-lactam antibiotics. To inhibit the work of b-lactamases, monocyclic b-lactams are being developed that block the active site of b-lactamases and cause bacterial cell lysis. In this project, novel beta-lactams containing dithiomethyl at C-4 position were synthesized and used to form new, potent biological active compounds, 1,2,3-tricarbonyl systems and unusual amino peptide.