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Antimicrobial properties of an orthodontic composite adhesive combined with cetylpyridinium chloride.

机译:正畸复合胶粘剂与十六烷基吡啶鎓氯化物的抗菌性能。

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摘要

An antimicrobial agent, cetylpyridinium chloride (CPC), was added to a commercially available light cured composite resin, and the antimicrobial and physical properties of the modified composite were evaluated. CPC was added at concentration of 2.5, 5.0 and 10.0 wt%. Discs were incubated with Streptococcus mutans for 48 hours. An agar disc diffusion assay was used to measure zones of bacterial growth inhibition for a period of 196 days. Discs were soaked in distilled water for a period of 180 days. The amount of CPC released from the modified discs into the water was measured and recorded on days 7, 15, 30, 60, and 180 using a spectrophotometer. Diametral tensile strength of the modified composite discs was measured with a universal testing machine, and the effect of water aging on diametral tensile strength was also evaluated by soaking CPC-composite discs in distilled water at 37°C for a period of 178 days. Results showed an increase in the measured zone of bacterial growth inhibition as CPC content increased. All CPC-composite samples maintained their antimicrobial activity up to 196 days. No zone of growth inhibition was measured around the control samples. The CPC release was observed through the end of 180-day period; but the largest amount of release was recorded in the first week (day 7). There was no significant difference (P .05) in diametral tensile strength between 2.5% CPC-composite group and the original product; whereas, there were significant differences among the 5.0 and 10.0% CPC-composite groups and the control. Water aging demonstrated no significant effect on diametral tensile strength except for test group containing 10.0% CPC. In conclusion, the incorporation of 2.5% CPC on composite material imparted antimicrobial activity to the original composite without altering its physical properties.
机译:将抗菌剂氯化十六烷基吡啶鎓(CPC)添加到市售的光固化复合树脂中,并评估改性复合材料的抗菌和物理性能。加入CPC的浓度为2.5、5.0和10.0重量%。将盘与变形链球菌一起孵育48小时。琼脂圆盘扩散测定法用于测量细菌生长抑制区域,持续196天。将圆盘在蒸馏水中浸泡180天。使用分光光度计在第7、15、30、60和180天测量并记录从改性圆盘释放到水中的CPC量。用万能试验机测量改性复合材料圆片的径向拉伸强度,并通过将CPC复合材料圆片在37℃的蒸馏水中浸泡178天来评估水老化对径向拉伸强度的影响。结果显示,随着CPC含量的增加,所测量的细菌生长抑制区域增加。所有CPC复合样品均保持其抗菌活性长达196天。在对照样品周围未测量到生长抑制区。在180天结束时观察到CPC的释放;但是在第一周(第7天)记录了最大的释放量。 2.5%CPC复合材料组与原始产品之间的径向拉伸强度没有显着差异(P <.05);而5.0和10.0%的CPC复合组与对照组之间存在显着差异。除含有10.0%CPC的试验组外,水老化对直径拉伸强度没有明显影响。总之,在复合材料上加入2.5%的CPC可以赋予原始复合材料以抗菌活性,而不会改变其物理性能。

著录项

  • 作者单位

    University of Illinois at Chicago.;

  • 授予单位 University of Illinois at Chicago.;
  • 学科 Biology Microbiology.; Health Sciences Dentistry.; Engineering Materials Science.
  • 学位 M.S.
  • 年度 2004
  • 页码 48 p.
  • 总页数 48
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;口腔科学;工程材料学;
  • 关键词

  • 入库时间 2022-08-17 11:43:22

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