Does the amount of surgical insult affect bone around moving teeth?

摘要

Purpose. To determine whether the amount of surgical insult affects the quantity, quality and maturity of dento-alveolar bone around teeth that are orthodontically moved. Methods. A split-mouth design was used in six foxhound dogs to compare bone surrounding the maxillary second premolars; the maxillary first premolars were extracted and the inter-septal bone was removed to within 1 mm of the second premolars in both experimental groups; the INSULT side had buccal and lingual vertical grooves made within the extraction socket to undermine the mesial root of the second premolar; the INSULT+ side was flapped, and modified corticotomies extending to, but not through, the lingual cortex were created 1mm distal to the distal root, and 3-5mm apical to both roots. Micro-CT was used to evaluate the material density, volume, and trabecular number, thickness and separation of bone surrounding the experimental teeth. H&E-stained slides were evaluated to determine osteoclast populations, bone surface, and bone volume. Results. After seven weeks of consolidation, the INSULT+ group showed decreased material density, buccal bone volume, and maturity. Relative to controls, the INSULT+ group showed decreased material density, maturity, but no difference in bone volume. The histological evaluation showed increased osteoclasts and bone surface, but no differences in bone volume. Conclusions. In response to increased surgical insult, the bone becomes less dense and mature, but bone volume is unaffected nine weeks post-surgery.