AlPcS(2a)--mediated photochemical internalization of bleomycin and concurrent hyperthermia of multicellular tumor spheroids.

摘要

Treatments for glioblastoma multiforme and invasive ductal carcinoma involve surgical resection and adjuvant or concurrent targeted therapies. The goal of the secondary treatment is to reduce the cancer cells in the resection margin and other areas of suspected involvement. Photochemical internalization is a targeted therapy using light to activate photosensitizers embedded in cellular structures to improve the delivery of macromolecules within the cell.;In a previous study, optimized treatment parameters including radiant exposure, and irradiance, concentration of AlPcS(2a), temperature, and the concentration of bleomycin were determined for human ACBT glioma multicell spheroids. The current study investigates the effectiveness of the ACBT–optimized concurrent PCI/hyperthermia treatment for F98 rat glioma and MCF-7 human invasive ductal carcinoma spheroids. The combination of photochemical internalization and hyperthermia was shown to be more effective than either treatment modality alone and, in all cases, the combined treatments interacted in a synergistic manner.