Investigation of the High-Throughput Analytical Performance of an FPA-FTIR Imaging System.

摘要

Focal plane array (FPA) FTIR imaging spectroscopy provides unprecedented levels of spatially resolvable chemical information for analysis of samples at the micrometer scale. This study evaluates the quantitative performance characteristics of the individual detector elements comprising the FPA camera, and applies them to making analytical measurements of a custom designed microfluidic multichannel transmission cell. Statistical descriptions are provided for the response distributions among the FPA's detector elements; RMS noise, peak response, and linear regression parameters. It was found that individual detector elements of the FPA allowed for accurate milli-absorbance measurements, however the variability was large when contrasting detector elements due to FPA detector non-uniformity issues. When applied to the microfluidic multichannel sampling system designed for the monitoring of four fluid streams, it was found that the detector elements covering the fluid stream could be averaged to generate a very repeatable response between streams---thus allowing for milli-absorbance measurements of 4 samples simultaneously with the current design.