Regio- and diastereoselective hydroformylation of homoallylic alcohols.

摘要

Scaffolding ligand, 14, was designed to direct the hydroformylation of 1,2 disubstituted alkenes, such that the aldehyde forms at the carbon distally from the directing group. The ligand has the ability to form reversible covalent bonds with the substrate and bind to the metal to achieve high conversion, regio- and diastereoselectivity of homoallylic alcohol products.