Local application of the bisphosphonate zoledronate to provide maximum anchorage for extraction space closure in rats.

摘要

Purpose. Orthodontists traditionally have used various physical means to prevent unwanted tooth movement. The aim of this study was to determine if local application of the bisphosphonate zoledronate could be used to prevent unwanted tooth movement during extraction space closure in rats. Methods. The upper left 2nd molar was protracted into the extraction space of the 1st molar for 21 days. Fifteen controls received a local injection of phosphate-buffered saline while fifteen experimentals received 16 mug of the bisphosphonate zoledronate. Cephalograms and incremental thickness gauges were used to measure tooth movements. Tissues were analyzed by muCT and histology. Results . The experimental group showed no tooth movement. muCT and histological observations revealed significant differences between the groups with no signs of osteonecrosis. Conclusions. A single, small, locally applied dose of zoledronate safely provided maximum anchorage while preventing significant bone loss. Zoledronate has potential to be used in many applications in dentistry.