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Salivary cortisol as a biological marker for screening enlisted submariners.

机译:唾液皮质醇作为筛选入伍潜艇的生物标记。

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摘要

Submarine duty in the United States Navy is considered to be one of the most stressful assignments in the military. The submarine community requires psychological screening, SUBSCREEN, prior to Enlisted Submarine School (BESS). SUBSCREEN is used to evaluate for specific traits, such as claustrophobia, that are incompatible with submarine service, as well as general psychological fragility. Currently there are no biological sampling techniques used in this evaluation process. Despite the current screening, 18.5% of the submariners who graduate from BESS do not complete their first tour, costing the Navy {dollar}33.3 million dollars annually.; This correlation design compared SUBSCREEN scores to various indices of cortisol activity of sailors during BESS training. The purpose was to evaluate the relationship of the SUBSCREEN scores and a biological marker of stress to determine the potential value of the additional screening. A long-term objective of the study is to determine if salivary cortisol levels predict attrition in the fleet.; The results of this study show little correlation of the cortisol activity and the SUBSCREEN, suggesting that they are testing discrete aspects of individual differences. The results of this study will present preliminary evidence for future longitudinal studies to evaluate cortisol activity in submariners who are more chronically stressed.; The secondary purpose of the study was to compare the gold standard ELISA to a newly developed assay by the Naval Institute of Dental and Biomedical Research utilizing fluorescence polarization. This assay exploits technology that has been available for serum, but not for saliva. This assay offers real time results in only three minutes and may prove valuable for far forward deployed stress studies.
机译:美国海军的潜艇任务被认为是军队中压力最大的任务之一。潜艇界需要在入伍潜艇学校(BESS)之前进行心理筛查(SUBSCREEN)。 SUBSCREEN用于评估与潜水艇服役不兼容的特定特征,例如幽闭恐惧症,以及一般的心理脆弱性。当前,此评估过程中未使用任何生物采样技术。尽管进行了目前的筛选,但从BESS毕业的潜水艇中仍有18.5%的人没有完成首次巡回演出,每年花费海军{33,300,000美元}。这种相关性设计将SUBSCREEN得分与水手在BESS训练期间皮质醇活性的各种指标进行了比较。目的是评估SUBSCREEN分数与压力的生物学标记之间的关系,以确定额外筛查的潜在价值。该研究的长期目标是确定唾液皮质醇水平是否可预测船队的人员流失。这项研究的结果显示皮质醇活性和订阅者之间几乎没有相关性,表明他们正在测试个体差异的离散方面。该研究的结果将为未来的纵向研究提供初步证据,以评估长期压力更大的潜艇人员的皮质醇活性。该研究的第二个目的是将金标准ELISA与美国海军牙科与生物医学研究所利用荧光偏振法开发的新方法进行比较。该测定法利用了可用于血清而非唾液的技术。该测定法仅需三分钟即可提供实时结果,对于进一步开展压力研究可能证明是有价值的。

著录项

  • 作者

    Osborne, Lisa A.;

  • 作者单位

    Rush University, College of Nursing.;

  • 授予单位 Rush University, College of Nursing.;
  • 学科 Health Sciences Nursing.
  • 学位 D.N.Sc.
  • 年度 2006
  • 页码 103 p.
  • 总页数 103
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

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