Blood glucose level regulation using higher order sliding mode techniques.

摘要

Diabetes is a serious disease during which the body's production and use of insulin is impaired, causing the glucose concentration level to increase in the bloodstream, Different methods have been employed to maintain this concentration at its basal value independent of daily insulin injections, which is the current treatment for this disease. In this dissertation, higher order sliding mode control techniques, including the prescribed convergence law, the quasi-continuous, and the Super-Twisting control algorithm, are studied for the stabilization of the glucose concentration level in a diabetic patient. The double loop structure of the proposed algorithm is appropriate for insulin delivery pumps in closed loop control of diabetes, where dynamics of the actuators must be addressed. The higher order sliding mode differentiator is employed to facilitate the controllers. Two sampling rates are successfully employed in the simulations: a smaller one for the system and the controller and the larger one for the glucose sensor. The performance of the proposed methods has been verified via computer simulations.