Studies of organosulfur and organoselenium compounds from selenized yeast and mushrooms.

摘要

Selenium compounds with potent anticancer activity have been under review for many years. Several selenoamino acids have been used for suppression of tumor development in rodents. A previously unreported selenoamino acid, S-(methylseleno)-cysteine, having a Se-S bond was synthesized and confirmed as a natural product of selenized yeast. The natural product was shown to be different from the synthetic sample of the isomeric compound Se-(methylthio)selenocysteine.;Isolation, characterization, and synthetic studies of sulfur-containing peptides of Marasmius alliaceus (garlic Marasmius ) and shiitake mushrooms were performed. Further information regarding their structure was obtained. The degradation process for the formation of the volatile substances previously identified in the mushroom was also studied. A novel regioselective oxidation method was used and provided an efficient route for the synthesis of marasmine.