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Interaction of stilbene compounds with the estrogen receptor.

机译:二苯乙烯化合物与雌激素受体的相互作用。

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摘要

Stilbene-related pharmaceuticals and personal care products have been detected in sewage effluents and surface waters. The effects of a suite of stilbene-related personal care products and pharmaceutical products were tested in vitro on the human estrogen receptor and rainbow trout estrogen receptor and in vivo in rainbow trout using the vitellogenin biomarker test. The results indicated that many of these compounds behaved similar to known pharmaceutical inhibitors, and the most common structural similarity, in addition to the stilbene backbone, was the presence of the 4-hydroxy phenyl group. Stilbene products found to act as inhibitors at the estrogen receptor include a group of plant-derived compounds including resveratrol, a dietary supplement, and DSBP a fluorescent whitening agent that is a common textile detergent additive. The presence of pharmaceuticals and personal care products in the environment will challenge traditional models and risk assessment frameworks for predicting effects due to their upredictable effects at low doses and atypical environmental behavior.
机译:在污水和地表水中已检测到与二苯乙烯相关的药物和个人护理产品。使用卵黄蛋白原生物标志物测试在体外对人雌激素受体和虹鳟鱼雌激素受体测试了一套与二苯乙烯有关的个人护理产品和药品的效果,并在体内对虹鳟鱼的雌激素受体进行了测试。结果表明,这些化合物中的许多化合物的行为与已知的药物抑制剂相似,除二苯乙烯骨架外,最常见的结构相似性是4-羟基苯基的存在。被发现在雌激素受体上起抑制剂作用的二苯乙烯产品包括一组植物来源的化合物,包括白藜芦醇,膳食补充剂和DSBP荧光增白剂,后者是一种常见的纺织品洗涤剂添加剂。环境中药品和个人护理产品的存在将挑战传统的模型和风险评估框架,因为它们在低剂量和非典型的环境行为下具有可预测的作用,因此可预测作用。

著录项

  • 作者

    Simmons, Denina B. D.;

  • 作者单位

    Trent University (Canada).;

  • 授予单位 Trent University (Canada).;
  • 学科 Health Sciences Toxicology.
  • 学位 M.Sc.
  • 年度 2006
  • 页码 108 p.
  • 总页数 108
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学(毒理学);
  • 关键词

  • 入库时间 2022-08-17 11:39:51

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