Selective syntheses of metal nanoparticles and characteristics of the interactions between metal nanoparticles and blood.

摘要

This thesis describes some novel methods to synthesize metal nanoparticles with specific sizes and shapes, either in solution or on silicon surfaces. Generally, the metal nanoparticles can be obtained via thermal decomposition as well as galvanic displacement. We have also demonstrated the unique properties of amphiphilic block copolymers in size and shape selectivity and in surface patterning.; Since there are many possible routes for the nanoscale materials to enter the blood circulation system, we also investigated the interactions between metal nanoparticles and blood samples. The reactivity, stability, and aggregation state of such metal nanomaterials was examined both in simulated blood plasma solutions, with or without bovine serum albumin, and in real human blood samples, including blood plasma, blood serum, and whole blood.