Magnetic resonance spectroscopic imaging of gamma-knife targeted neoplasms: The SIGN project launch.

摘要

This report of the Spectroscopic Imaging of Gamma-Knife-targeted Neoplasms (SIGN) Project Launch is a detailed step-by-step account of a clinical project designed to integrate cutting edge technologies in a way that improves patient treatment. Objective. The aim of this early study is to implement and optimize the use of spectroscopic imaging for Gamma Knife-Targeted neoplasms. Methods. Acquisition of Proton Magnetic Resonance spectroscopic imaging (1H-MRSI) phantom and patient data sets using GE Signa LX 1.5T MRI scanner and incorporation into Gamma Knife stereotactic radiosurgery (GK-SRS) treatment planning workstation. Results. Successful metabolite mapping was obtained with 1H-MRSI for a patient with a glioblastoma multiforme (GBM) at the time of GK-SRS. Conclusions. As a result of this project launch, more work with 1H-MRSI for brain tumors is now going ahead at our centre (Health Sciences Centre, Winnipeg, Canada).